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740 evidence-based articles organized by what changes after 40 — and what the research actually says works. Every numeric claim is sourced to peer-reviewed research (PMID/DOI required) and medically reviewed by Dr. Daniel Yadegar, MD, FACC, RPVI.
NAD+ is the molecule your cells burn for energy. After 40, NAD+ levels drop ~30% per decade. These articles explain what NAD+ does, the difference between NMN / NR / NMNH precursors, and what the research says works.
→ Read the NAD+ supplementation pillar
Perimenopause typically starts in the mid-40s and lasts a decade. Estrogen, progesterone, FSH, and DHEA all swing. These articles cover what to expect, what helps, and what the evidence does NOT support.
→ Read the Perimenopause pillar
Cortisol shifts, progesterone drops, and core body temperature regulation all change after 40 — and sleep is usually the first thing to go. Evidence-based protocols for falling asleep, staying asleep, and protecting REM.
→ Read the Sleep architecture pillar
GLP-1 medications (Ozempic, Wegovy, Mounjaro, Zepbound) work — but cause muscle loss, nutrient deficiencies, and protein gaps if uncoached. These articles cover protein targets, micronutrient support, and what to eat on GLP-1.
→ Read the GLP-1 receptor agonist therapy pillar
Cortisol, insulin, thyroid, sex hormones — they all interact. After 40 the regulation gets noisier. Adaptogens, micronutrients, and timing protocols backed by RCT evidence.
→ Read the Endocrine balance pillar
Stomach acid drops ~30% by 40 and motility slows. Bloating after meals is often misattributed to food intolerance when the real culprit is gastric emptying. Evidence-based fixes.
→ Read the Postprandial bloating pillar
The 12 hallmarks of aging (López-Otín et al., Cell 2013) are the canonical framework. These articles trace each hallmark to what you can actually do about it before 65.
→ Read the Longevity medicine pillar
The five years before perimenopause are the highest-leverage longevity window. Mitochondrial function, hormonal trajectory, bone density, and metabolic rate all set their post-40 baseline here.
→ Read the Women's longevity pillar
This page is updated weekly with new evidence-based articles from the Happy Aging editorial team. Articles are produced under our Editorial Policy and reviewed by Dr. Daniel Yadegar before publication. Read more about our editorial team.
Statements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease. Always consult your healthcare provider before starting any new supplement.
